A group of Russian scientists have proven the effectiveness of using short, modified pieces of DNA, to restore sensitivity to a drug for anti-tumor chemotherapy for cervical cancer, Russian news agency ITAR-TASS reported.
“Institute scientists are synthesizing compounds called the modified Oligonucleotide, which are short fragments of DNA with associated chemical groups that give the formed DNA additional useful properties,” said Oleg Markov of the Institute of Chemical Biology and Basic Medicine at the Russian Academy of Sciences. “These compounds are promising in the production of new generation drugs,” he said, adding that for many years, the main problem has been the effective transfer of the drugs that were created inside the cell.
According to the agency, Markov said: “Earlier, the institute developed a way to introduce different chemical groups into DNA nucleotides using an DNA robot. Currently, chemists have focused on bringing fat-like fragments from molecules into glutinocleutide, allowing compounds that have been created to link to and penetrate cell membranes and penetrate inside. It turns out that the increase in the number of fat populations introduced can significantly increase the efficacy of hacking into compounds studied in human cells, without showing toxic symptoms.” Thanks to this discovery, scientists have been able to create “combat” chemical compounds that summarize their biological effect in curbing and stopping the gene that is responsible for the resistance of cancer cells to conventional anti-cancer drugs used in treatment.